Protease inhibitor-induced cardiotoxicity: direct effects on cell viability and intracellular calcium levels

doi:10.1186/1758-2652-11-S1-P91

Journal of the International AIDS Society
Volume 11
Suppl 1

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Spiers JP
Edwards C
Rietz A
Jan E
Mulcahy F
Hennessy M
Volkov Y
Davies AM

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Spiers JP
Edwards C
Rietz A
Jan E
Mulcahy F
Hennessy M
Volkov Y
Davies AM
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This article is part of the supplement: Abstracts of the Ninth International Congress on Drug Therapy in HIV Infection .

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Protease inhibitor-induced cardiotoxicity: direct effects on cell viability and intracellular calcium levels

JP Spiers¹, C Edwards¹, A Rietz¹, E Jan², F Mulcahy³, M Hennessy¹, Y Volkov¹ and AM Davies¹

¹Trinity College Dublin, Dublin, Ireland

²University of Michigan, Michigan, USA

³St James' Hospital, Dublin, Ireland

corresponding author email

from Ninth International Congress on Drug Therapy in HIV Infection
Glasgow, UK. 9–13 November 2008

Journal of the International AIDS Society 2008, 11(Suppl 1):P91doi:10.1186/1758-2652-11-S1-P91


Published:	10 November 2008

First paragraph (this article has no abstract)

Long-term use of protease inhibitors (PIs) is associated with increased cardiovascular risk linked to metabolic imbalance and endothelial dysfunction. The direct effects of PIs on cardiomyocytes have not been studied, but may be critical to our understanding of the cellular mechanisms contributing to ART-associated cardiovascular dysfunction in HIV patients. This study aims to assess the effects of antiviral agents on cell survival and intracellular calcium levels in cardiomyoblasts (H9c2).