|
|
||||
| Fold Induction |
||||
|
|
||||
| Approx. Clinical Conc |
PXR/CYP3A4 |
CAR/CYP3A4 |
PXR/CYP2B6 |
CAR/CYP2B6 |
|
|
||||
| IDV (15 μM) |
1.3 |
<1 |
1.5 |
<1 |
| NFV (6 μM) |
6.1 |
<1 |
3.0 |
<1 |
| LPV (16 μM) |
9.1 |
<1 |
8.6 |
1.6 |
| RTV (1 μM) |
1.9 |
<1 |
2.1 |
<1 |
| TFV (1 μM) |
<1 |
1.2 |
ND |
ND |
| SQV (4 μM) |
3.2 |
<1 |
ND |
ND |
| NVP (7.5 μM) |
<1 |
1.1 |
<1 |
1.6 |
| EFV (10 μM) |
5.8 |
<1 |
2.6 |
<1 |
| FOS (13 μM) |
10.4 |
1.4 |
2.9 |
1.3 |
| Rifampicin (10 μM) |
18.3 |
--- |
15.9 |
--- |
| CITCO (100 nM) |
--- |
3.4 |
--- |
3.5 |
Svard et al. Journal of the International AIDS Society 2008 11(Suppl 1):P236 doi:10.1186/1758-2652-11-S1-P236 |
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