This article is part of the supplement: Abstracts of the Ninth International Congress on Drug Therapy in HIV Infection .

Oral presentation

O113 HIV-1 clade C resistance genotypes after first virological failure in a large community ART programme

C Orrell¹, RP Walensky², E Losina², KA Freedberg² and R Wood³

¹  Desmond Tutu HIV Centre, UCT, Cape Town, South Africa

²  Divisions of General Medicine and Infectious Disease, Massachusetts General Hospital, Harvard Med School and Harvard University, Harvard, USA

³  Desmond Tutu HIV Centre, Cape Town, South Africa

corresponding author email

from Ninth International Congress on Drug Therapy in HIV Infection
Glasgow, UK. 9–13 November 2008

Journal of the International AIDS Society 2008, 11(Suppl 1):O3doi:10.1186/1758-2652-11-S1-O3

Published:	10 November 2008

First paragraph (this article has no abstract)

In sub-Saharan Africa large numbers of clade C HIV-infected individuals are exposed to antiretrovirals through prevention of mother-to-child transmission and through first-line non-nucleoside reverse transcriptase inhibitor-based (NNRTI) regimens. HIV drug resistance pre-treatment, as well as in those failing first-line ART, has not been adequately catalogued. Choice of second-line therapy would ideally be based on patterns of resistance at first-line failure.